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Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor

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MC4R activation in renal tubular epithelium increases water reabsorption through aquaporin-2 channel upregulation, producing mild fluid retention (0.51.5 kg weight gain) in 812% of subjects over 714 days of repeated dosing

Hence, the pathophysiological role of LPL activity in NAFLD remains elusive ( Figure 4 )

For deeper compound-specific guides, see the PT-141 protocol and the afamelanotide protocol