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The autophagic response was identified as an essential mechanism of chemoresistance, since its inhibition eliminated the protective effect

The narrative format was selected to accommodate heterogeneous evidence spanning preclinical mechanisms, clinical trials, and translational barriers where systematic synthesis would be inappropriate

To verify the importance of HIF-1alpha in the defense against UPEC infection, the researchers studied mice with reduced HIF-1alpha levels

This interaction ultimately diminishes the transcriptional activity of the NF-B complex, and as a result, SIRT1-mediated deacetylation serves to inhibit NF-B signaling

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Firstly, the synthesis of GSH-depleted multicomponent nanomedicines is so time-consuming that it still faces a huge technological gap from laboratory preparation to industrial production ( 5 Conclusion and outlook Cancer cells show overexpressed GSH that may maintain redox homeostasis to protect cells from oxidative damage, as well as reduce the chemotherapeutic agent-induced toxification