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During acute inflammation of the lungs, a deficient apoptotic cell clearance is overcome by the recruitment of mononuclear phagocytes and following the binding of foreign particles (viruses or apoptotic bodies) alveolar macrophages initiate inflammation and host defense reactions (88, 109)

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Dev Biol 296(1):177189 Kalin RE et al (2007) Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis