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in 2020, 42% of the clinical trials in the USA were biomarker-based, compared to only 5% in 2005

Schwartz CL, Wexler LH, Krailo MD, et al

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The authors argue that this is a missed opportunity because the TDLN is a place where tumor antigens are first processed and presented to the immune system, and where the balance between immune activation and immune tolerance may be decided early

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DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD