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Subsequent to the discovery of OCTN2 gene (SLC22A5), molecular analysis has become a routine test to establish definitive diagnosis when patients present with symptoms (clinical symptomatic patients)

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Although both acetyl-l-carnitine and gabapentin provided significant pain relief, acetyl-l-carnitine (100 mg/kg, i.p., 14 days), but not gabapentin (70 mg/kg, i.p., 14 days), significantly prevented nerve fibre and myelin thickness loss and increased axonal neurofilament immunoreactivity [16]