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After 48 h of treatment, immunostaining with anti-3 tubulin was performed

Treatment of the 3xTgAD Alzheimers disease model mice with ketone ester [(R)-3-hydroxybutyl-(R)-3-hydroxybutyrate], which is metabolized into two molecules of the ketone body beta-hydroxybutyrate, increased the cerebral cortical cytoplasmic [NAD + ]/[NADH] by 70% (from 230 to 390) and increased the hippocampal [NAD + ]/[NADH] by 65% (from 250 to 410), as inferred from the increased pyruvate/lactate (Pawlosky et al., 2017)

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Other gingerol analogs, such as shogaols, paradol, and zingerone, are also found in high concentrations in this rhizome

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