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Mechanism of Action NSAIDs inhibit one or both COX enzymes: COX-1 Protects gastric mucosa Maintains renal blood flow Supports platelet aggregation COX-2 Induced during inflammation Produces prostaglandins involved in pain, swelling, and fever Traditional NSAIDs block both COX-1 and COX-2

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It enhances insulin sensitivity, promotes fat oxidation, improves exercise capacity, and supports cellular resilience

Cyano-B12 is the most commonly used, and cheapest, form of B12 with no substantial evidence that other forms are more effective in improving B12 status

Hence, this study was carried out to validate the experimental design that involved using zebrafish as a model for AD by conducting behavioural assessment involving anxiety and locomotion testing and employing the potent neurotoxin