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NEJM Evid

They suggested that the antimutagenic effect of riboflavin can, at least in part, result from its direct scavenging activity on free radicals produced by mutagens

Among natural permeation enhancers, terpenes such as -bisabolol that have gained attention due to their ability to interact with mucosal lipids, enhancing drug permeability without affecting tissue integrity, as demonstrated in vitro studies using porcine mucosa in small drug molecules [95]

Do not use within 3 hours of bedtime as it may interfere with sleep

The study was retrospectively listed on a clinical trials database, ISRCTN99373118