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Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide

2013;8(8, article e71272) doi: 10.1371/journal.pone.0071272

Folic acid, vitamin B-12, and vitamin B-6