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Heller DS

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Salmanoglu DS, Gurpinar T, Vural K, et al

Krishnan J, de la Visitacion N, Hennen EM, Amarnath V, Harrison DG, Patrick DM

For a diagnosis of NF1 to be made, at least two of the following symptoms should be present: Six or more CALMs, with a size greater than 5mm in children or over 15mm in adults At least one plexiform neurofibroma, which is a type of benign tumor, or any two other types of neurofibromas Freckles in the armpit or groin area, a sign indicative of NF1 Optic glioma, a type of brain tumor affecting the eyes Two or more Lisch nodules, which are benign growths on the iris of the eye A distinct bone abnormality, like abnormal bone thinning or a condition causing false joints in the bone A first-degree relative, such as a parent, sibling or child, with a diagnosis of NF1 There are other genetic syndromes associated with multiple CALMs, including Neurofibromatosis type 2 (NF2), McCune Albright Syndrome, Legius syndrome, Watson Syndrome, and Noonan syndrome with multiple lentigines (also known as LEOPARD syndrome)

This guideline highlights the key visual characteristics to watch for in a mole or skin lesion

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