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In our specific approach, we suggest that the glutathione cycle may be one such source of this glutamate

For cultured astrocytes, the processes that are mainly responsible for the consumption of intracellular GSH aredepending on the experimental conditions appliedthe oxidation of GSH to GSSG by GPx, the conjugation of GSH with electrophiles, and/or the export of GSH, GSSG, and GSHconjugates (Figure 2)

However, they are not FDA-approved for any human therapeutic use, and long-term safety data is limited

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JAMA 2007

Some are considered temporary solutions, although some cortisone shots successfully treat shoulder pain permanently