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doi: 10.1158/0008-5472.CAN-06-1648 431 WangFZhangDZhangQChenYZhengDHaoLet al

Mol pharmaceutics (2018) 15(8):303245

Some trials observed effects on IGF-I and protein metabolism, suggesting MK-677 may play a role in managing muscle-wasting conditions, although the exact mechanism and long-term benefits are still under investigation

In the liver, however, where the substrate conditions are different the GDH reaction may well be at thermodynamic equilibrium (15)

Adv Clin Exp Med (2017) 26(9):14315

Alternatively, increased 3-HIA in isolation could reflect metabolic alterations that occur during pregnancy, such as increased protein turnover or renal handling of organic acids during pregnancy (19)