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TSH is the most sensitive marker, and high TSH and low free T4 confirm primary hypothyroidism

Some contain cheaper and less absorbable ingredients

Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors

The colon lining needs both a tight barrier and good micro-blood flow to heal

A simpler and cheaper way is to take a single dose a week
These are all reasonably typical effects of dietary deficits
