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Keeler AM, Flotte TR

Moreover, SGLT2 inhibitors promote weight loss in many individuals and decrease the risk of major cardiovascular events

After 8 weeks of oral administration of 500 mg BID propionate to individuals with hyperlipidemia, various blood lipid components exhibited notable reductions in TC, LDL-C, and non-HDL cholesterol [85]

Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

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