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TABLE 1 Overview of the small molecule inhibitors targeting NNMT

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Disclosed herein are cyclobenzaprine analogs that demonstrate inhibition of the 5HT2a receptor (seeFIG

10.1038/s41573-019-0017-4 127 ShiL.LiuX.-Y.HuangZ.-G.MaZ.-Y.XiY.WangL.-Y.et al (2019)

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Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific