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This process is vital for cellular innate immunity, as it helps combat pathogens, dysfunctional organelles, sarcomeres, and pathologically aggregated proteins [33]

Lu and Atkins, 2004)

A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

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doi:10.1080/1028415x.2017.1352121 42

Exposure to environmental xenobiotics may be inadvertent and accidental orwhen they are present as components of air, water, and foodinescapable