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Interestingly, as desensitization involves a number of steps including receptor phosphorylation, -Arr recruitment, and internalization or degradation, aberrations at any level may precipitate disease

It also includes the change of a molecule's shape to make it irreversibly altered, such as the denaturing of proteins, and the addition of other atoms or molecules

Dabrowska, K

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Ethics declarations Ethical approval Institutional Animal Ethics Committee (IAEC) has approved the protocol (Approval Number: MLRIP/IAEC/2018/02)

Additionally, chemical intermediates capable of neutralizing reactive species are formed, such as phenolic compounds oxidized by peroxidases, which generate phenoxide radicals that can act as antioxidants (Anggraini et al