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In the subsequent sections, we summarize important characteristics of methionine and methionine-derived metabolites, and highlight its roles in signaling and metabolism, as well as in translation (beyond being the first amino acid encoded in a polypeptide)

Blood Cancer 65 , e27313 (2018)

The solvent Another possible cause of painful B12 injections is the solvent used to dissolve the B12 in the vial

I heard someone mention there is some genetic variant which may be at play here