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Together, the above factors determine how glutamine metabolism in the TME affects the immune response, eventually causing tumor progression or suppression
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ABCB11 , ABCB4 , ABCC2 , and ABCG5 /8 gene mutations can result in benign cholestatic syndromes such as BRIC, ICP, and DJS, or severe disease such as PFIC and sitosterolemia
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