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Due to its cardiovascular focus, Propionyl L Carnitine shows most substantial evidence for peripheral arterial disease (73% improvement in walking distance), intermittent claudication (significant symptom reduction), heart failure (improved ejection fraction), and male fertility (37% sperm motility enhancement), with effective doses ranging from 1,000-3,000mg daily typically divided into 2-3 administrations

In rare cases, it may cause stomach pain, stomach upset, diarrhoea, nausea, and vomiting

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The expression level of glucose transporter type 4 (GLUT4) gene is reduced in pinealectomized animals, which consequently results in glucose intolerance and insulin resistance

doi: 10.1038/ncpuro0201