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This in turn requires the availability of reliable tools for confirming the diagnosis of OS and evaluation its severity

Implications Despite the above limitations, our findings carry several important implications for clinical practice, public health, and policy

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5,10-Methylene tetrahydrofolate (THF) is required for the synthesis of nucleic acids and is reduced to 5-methyl THF by methylene THF reductase, a flavin-dependent enzyme that uses NADPH as a cofactor