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These ECM fibres also govern cell migratory tracks, which can restrict the inter action of immune cells with cancer cells 122 (FIG

doi: 10.1002/path.5351 93 GuS.XuM.ChenL.ShiX.LuoS.-Z

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The SIRT3 deficiency triggers a decline in renal function, a significant increase in inducible nitric oxide synthase (iNOS), and upregulation of the expressions of toll-like receptor 4 (TLR4), NF-B, inhibitor of Kappa B (IB), inhibitor of kappa B kinase (IKK), and p65 proteins