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Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)

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In the case of diabetes, disorders in lipid peroxidation, enzymatic systems as well as impaired glutathione metabolism are observed

[DOI] [PMC free article] [PubMed] [Google Scholar] 172.de Groot S., Lugtenberg R.T., Cohen D., Welters M.J.P., Ehsan I., Vreeswijk M.P.G., Smit V., de Graaf H., Heijns J.B., Portielje J.E.A., et al

A central component in this cascade is the kinase Akt, also called protein kinase B (PKB), which controls both protein synthesis, via the kinases mammalian target of rapamycin (mTOR) and glycogen synthase kinase 3 (GSK3), and protein degradation, via the transcription factors of the FoxO family