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Specifically, it upregulates specific microRNAs (miRNAs) to silence the expression of two critical molecules: miR-155, miR-181b, and miR-361 target Aicda, whereas miR-23b, miR-30a, and miR-125b target Prdm1 (encoding B lymphocyte-induced maturation protein-1, Blimp-1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 307.Arafah A., Khatoon S., Rasool I., Khan A., Rather M.A., Abujabal K.A., Faqih Y.A.H., Rashid H., Rashid S.M., Bilal Ahmad S., et al

In addition, D-mannose exerted a chondroprotective effect by attenuating the sensitivity of chondrocytes toward ferroptosis and alleviating OA progression

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miR-34a5p upregulates the IL1/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons

[DOI] [PubMed] [Google Scholar] 42.Garrouste FL, et al
