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Specifically, cytokines secreted by Th1 and Treg cells (e.g., IFN-, IL-2) decrease, while those from Th2 and Th17 cells (endocrine IL-1, IL-4, IL-6) increase, suppressing immune function and promoting apoptosis (150)

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doi: 10.1038/s41598-018-34303-z 10 ThabetAAEbidAAEl-BoshyMEAlmuwalladAOHudaimoorEAAlsaeediFEet al

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After having first improved, one patient subsequently worsened, with clinical symptoms and a new pattern of brain hypometabolism (102)

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& Winkler, A

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