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Vitamin B12 deficiency has been associated with peripheral neuropathy and even cognitive deficits, especially in older adults and those with HIV/AIDS, where it supports nerve function and assists in the maintenance of myelin sheath integrity

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10.1007/s10534-005-6666-2 [DOI] [PubMed] [Google Scholar] Liu J., Liu W., Liu Y., Miao Y., Guo Y., Song H., et al

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On the other hand, diosgenin and charantin are the steroidal sapogenins having higher lipid solubility, hence have least volume of distribution, which affects their bioavailability