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If fatigue continues, a clinician may evaluate anemia, thyroid disease, sleep problems, medication effects, mood concerns, or other causes

While the flow cytometric apoptosis reduction (3.48%) was not statistically significant, the molecular markers (caspase-3 down 42.7%, PARP down 77.5%, Bcl-2/Bax shift) were all highly significant

McGuire et al

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

4) Stem Cells - along with PRF, preliminary evidence suggests autologous mesenchymal stem cell therapy may provide an enhanced stimulus of growth factors for tendon repair

The trade-off involves doubling the number of injections required