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Consensus on wound antisepsis: update 2018

The enzymes regulating the methyl transfers in the production of glycine from betaine are successively the cytosolic enzyme betaine-homocysteine S-methyltransferase (BHMT), and the mitochondrial enzymes dimethylglycine dehydrogenase (DMGDH) and sarcosine dehydrogenase (SDH)

N Engl J Med (2010) 362(18):167585

Catalase has also been studied in a number of different diseases in which OS is implicated, such as, diabetes mellitus where patients presented lower CAT values [61]

A limitation of this study is the relatively small cohort size and lack of patients treated by checkpoint blockade

This inverse relationship between the levels of GSH and MDA is to be expected, which reveals that as the levels of GSH dwindle among the diabetic individuals, their redox homeostasis becomes subverted as well, resulting in increased systemic oxidative stress