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it was studied by Novo Nordisk and later Helsinn Therapeutics, including a Phase II trial for postoperative ileus, but development was discontinued for lack of efficacy

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Nat Rev Microbiol 5:441452

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Danilkovitch-Miagkova A., Zbar B

However, since small intestinal permeability was significantly higher in patients with alcoholic liver diseases than in patients with chronic alcohol abuse in the absence of liver disease, the direct barrier toxicity of alcohol does not fully account for the permeability defect (155)