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We also demonstrated that GSH in combination with cytokines such as IL-2 and IL-12 enhances the functional activity of natural killer (NK) cells to inhibit the growth of M

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Aging is associated with a shift to using glutamine to create TCA cycle intermediates due to increased energy needs from mitochondrial dysfunction, so this increase in expression could be in response to increased oxaloacetate from the TCA cycle

10.1038/nrgastro.2017.136 299

The pathophysiological and biochemical process of cisplatin nephrotoxicity is very complex and includes the drug accumulation in the tubular epithelial cells, activation of apoptosis via death receptors like TNF- and Fas in the plasma membrane, activation of endoplasmic reticulum stress or by cycle cell arrest [21]