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Cell Death Differ 25(3):486541 Gao J et al (2018) Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non-small cell lung cancer

doi: 10.1186/s13148-020-00913-6

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Although the trials safety monitoring board and sponsors ultimately deemed the event unrelated to the study compoundnoting the patient had multiple pre-existing cardiovascular risk factors common in advanced HIV populationsthe premature termination of the trial halted further clinical development of CJC-1295 DAC for commercial therapeutic use

Epigenetic alterations in prescription opioid misuse: new strategies for precision pain management