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The antitumor efficacy of combination therapy was achieved by inhibiting IGF-1-IGF-1R signaling in cancer cells, boosting the intratumoral CD8 cell: Treg ratio in the TME

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(Some patients may reuse their own syringe up to a few times if needed, but it must never be shared or used by someone else.) After injection, the used syringe should be placed in a proper sharps/needle container for safe disposal this prevents needlestick injuries or hygiene issues

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