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Cells were treated for 24 h with 0.1600 M NNMT inhibitors in cell culture media

Enterohepatic Circulation of Folates: Thirdly, after intestinal absorption, folates (mostly, monoglutamates) enter the hepatic portal system and are delivered to the liver, where it is either: (a) metabolized to polyglutamate derivatives and retained, or (b) it is released back into blood or bile

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doi:10.1038/s41598-022-10338-1 129