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2013 Jul 17;61(28):6769-75

Intracellular Accumulation of Advanced Glycation End Products Induces Osteoblast Apoptosis Via Endoplasmic Reticulum Stress

The CIR (Cosmetic Ingredient Review) has concluded this ingredient to be safe as used in cosmetics and it has not shown to be a skin sensitizer in testing (unless you have a known rice allergy)

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Also, the granulosa cells of the growing follicle secrete a variety of peptides that may play an autocrine/paracrine role in the inhibition of development of the adjacent follicles

Periyasamy P, Thangaraj A, Bendi VS, Buch S