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Burwinkel B, Kreuder J, Schweitzer S, Vorgerd M, Gempel K, Gerbitz KD, Kilimann MW: Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality
According to their results, oral administration of carnitine at a dose of 18 mg/kg significantly restored CPT activity and downregulated the serum levels of interleukin-6 (IL-6) and TNF- in animal models
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