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It is also noteworthy that MC1R activation might suppress the expression of COX-2 and cell adhesion molecules, suggesting a potential anti-inflammatory pathway through which MT-1 and similar compounds may exert further anti-fibrogenic action

Glossary Acute phase response The systemic inflammatory reaction to an infection or injury, including fever, tachycardia, leukocytosis and changes in circulating acute phase proteins, such as C-reactive protein

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The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

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