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Moderate and severe TBI carries substantially higher risks of long-term disability, including impaired memory, executive function deficits, emotional dysregulation, and increased vulnerability to neurodegenerative disease later in life

C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1

This process can be recapitulated ex vivo by placing pancreatic acinar cells into two-dimensional (2D) cell culture, which results, over time, in the loss of expression of the acinar marker amylase and in the increase in expression of the ductal marker, CK19 (ref

Wada, T., Tachibana, T., Shimura, Y

Regarding biochemical mechanisms, one of the primary biochemical processes involves using metabolites derived from nutrients as cofactors or substrates for epigenetic enzymes

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