alterations of dna methylation by glutathione depletion Oxidative stress influences chromatin modifiers. Chromatin modifying Frontiers | The epigenetic modification

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Although its contribution to energy metabolism in the healthy brain is minimal, it is an interesting metabolite which is not only oxidised but also has other direct and collateral effects which make it a molecule of interest for therapeutic purposes

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Oxidative stress is a major contributor to the pathophysiology of sickle cell disease (SCD) including hemolysis and vaso-occlusive crisis (VOC)