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Understanding of both host and viral factors may in the future lead to creation of new approaches in generation of an efficient therapeutic vaccine

It is intriguing though, that despite the mild impact on L-carnitine levels, patients affected by these diseases have marked brain alterations such as nondysmorphic autism (deficiency of 6- N -trimethyllysine dioxygenase) [60] and microcephaly and speech delay (deficiency of -butyrobetaine dioxygenase) [61]

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For instance, NAALADL2-AS2 is a novel CRPC-regulated lncRNA whose expression increased under ADT and controlled the expression of genes that regulate cell cycle and glycogen metabolism

These findings suggest that declining acyl-carnitine levels may be linked to the onset and progression of Alzheimers, potentially serving as biomarkers for early detection and intervention

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