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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

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The tripeptide, GHK, induces programmed cell death in SH-SY5Y neuroblastoma cells

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Given that skeletal muscle is the major site of carnitine storage within the body, and that maintaining hypercarnitinemia for 5h in the presence of hyperinsulinemia increases skeletal muscle TC accumulation (other Stephens Group studies), it is not unreasonable to suggest that this greater retention occurred mainly in this tissue. Given that the increase in muscle carnitine content following a single dose, or 2 weeks, of L-carnitine feeding in the presence of elevated circulating insulin is likely to be small due to the poor bioavailability of orally administered L-carnitine (less then 20%), muscle carnitine accumulation was estimated indirectly from measurements of plasma and urinary carnitine concentration

doi: 10.1016/j.biopha.2021.111315 194 JiaoPMaJFengBZhangHDiehlJAChinYEet al