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Studies have shown that cuproptosis leads to the release of mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING innate immune pathway, which in turn induces IFN production and immunogenic cell death (ICD), recruiting and activating cytotoxic T lymphocytes [105,106]

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Yazgan Y, Naziroglu M (2017) Ovariectomy-induced mitochondrial oxidative stress, apoptosis, and calcium ion influx through TRPA1, TRPM2, and TRPV1 are prevented by 17beta-estradiol, tamoxifen, and raloxifene in the hippocampus and dorsal root ganglion of rats