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Animal and cell experiments have demonstrated that vitamin D has a positive effect on preventing the exacerbation of COPD infections, which helps to enhance the defense ability of human bronchial epithelial cells against air pollution exposure (169), and can reduce the exacerbation of infections by regulating the expression of antibacterial peptides (170) and inhibiting related cellular inflammation and fibrosis responses (171)

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doi: 10.3389/fncir.2023.1218737 Received 08 May 2023 Accepted 04 September 2023 Published 20 October 2023 Volume 17 - 2023 Edited by Elsa Rossignol, CHU Sainte-Justine, Canada Reviewed by Sheketha R

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The more significant cosmetic changeslike a visible reduction in the look of fine lines and a firmer appearancetend to show up after about three months of dedicated use

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doi: 10.3109/13506129.2012.751367

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Nevertheless, their utilization may be disadvantageous due to their high cost, intense immunological responses, and oncogenic effects, which restrict their application [96,97,98]

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