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GCL activity is in part regulated by GSH feedback inhibition

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Glutathione (GSH), a well-known antioxidant molecule, may have therapeutic effects in countering this pathway of immunothrombosis as decreased levels of (GSH) have been associated with increased viral replication, cytokine levels, and thrombosis, suggesting that glutathione supplementation may be therapeutic for COVID-19

Astaxanthin as a king of ketocarotenoids: Structure, synthesis, accumulation, bioavailability and antioxidant properties

In this mechanism, ligand binding to the Fas cell membrane receptor directly stimulates the binding of the initiator caspase, caspase-8 [90]

Studies have shown that EVs secreted by MenSCs can function as exogenous ROS scavengers, thereby reducing the dependence of embryos from aged female mice on endogenous antioxidant proteins such as superoxide dismutase 1 (SOD1) and glutathione peroxidase 1 (GPX1), ultimately improving IVF outcomes (Marinaro et al., 2018)