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Generation and evaluation of truncated LRRK2 The identification of kinase-mediated cellular dysfunction has led to the development of several kinase inhibitors as therapeutic methods for LRRK2 silencing (see review by Zhao and Dzamko 23 )

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[DOI] [PubMed] [Google Scholar] 99.Savoia A, Landi S, Baldi A

Notably, CAPE binds to the enzymes active site without interacting with the catalytic Co 2+ ion, and this unique binding mechanism may reduce potential side effects on human metalloproteases [89]

An animal experiment demonstrated that CD38-deficient mice exhibited significant lower levels of amyloid plaques and soluble amyloid [98]