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This review comprehensively elucidates the regulatory networks of ferroptosis in OS, with a specific focus on the System Xc/Glutathione Peroxidase 4 (GPX4) antioxidant axis and lipid metabolism

Recent solution NMR structural studies have provided detailed molecular models of the p53 transactivation domain in complex with both the FOXO4 forkhead domain and FOXO4-DRI, advancing understanding of the precise molecular interactions that enable selective senescent cell targeting in research applications