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This triple-agonist compound, which is known for its action on GLP-1, GIP, and glucagon receptors, has become a key focus in metabolic and weight management studies

Thus, although the combination of anti-complement therapies with other anti-cancer agents should be further investigated, the increasing number of studies that demonstrate the improved antitumor responses obtained combining complement inhibitionand in particular C5aR1 inhibitionwith chemotherapy and/or immunotherapy, together with our present results on paclitaxel-mediated C5aR1 activation, further sustain that a combined treatment with paclitaxel and C5aR1 inhibitors could be a promising therapeutic approach, not only to prevent CIPN and HSRs, but also to potentially obtain a synergistic effect on tumor progression

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Ultraviolet radiationinduced cataract in mice: the effect of age and the potential biochemical mechanism

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