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Unlike NAD+ precursors that work downstream, 5-Amino-1MQ acts upstream by blocking NNMTs consumption of S-adenosyl methionine (SAM), resulting in elevated intracellular NAD+ and SAM levels without requiring direct nucleotide supplementation
[3] L-carnitine transports long-chain fatty acids across the inner mitochondrial membrane as acyl-carnitine esters, permitting -oxidation and ATP generation while simultaneously buffering toxic acyl-CoA accumulation
PMID: 31193945
[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Ong KT, Mashek MT, Bu SY, Greenberg AS, Mashek DG
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