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They may: Cause internalization and degradation of FR, reducing receptor availability

Furthermore, peripheral insulin resistance triggered by uremia, metabolic acidosis and low-grade inflammation is common in CKD (80), leading to intra-portal hyperinsulinemia, but does not necessarily increase hepatic sensitivity to GH because of the reduced hepatic expression of IGF-I and GHR mRNA (81)

Although there has been limited research on the role of Ag in liver fibrosis, its extensive pharmacological effects provide a strong rationale for its potential liver-protective and anti-fibrotic properties

Cuproptosis-associated genes (CAGs) contribute to the prognosis prediction and potential therapeutic targets in hepatocellular carcinoma

Cellular & Molecular Biology Research: Cell-based assays utilize these peptides to analyze intracellular signaling cascades and transcriptional responses