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While HSA acknowledges that some unregistered drugs may be safe due to a history of safe use, the registration status of a therapeutic product serves as an objective proxy for risk-classification of a trial to qualify for notification route

Stable Loading and Delivery of Disulfiram with mPEG-PLGA/PCL Mixed Nanoparticles for Tumor Therapy

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the electron flow through these transmembrane complexes lead to the pumping of protons across the inner mitochondrial membrane

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Furthermore, significant changes have been observed in the content of various proteins involved in mitophagy, mitochondrial dynamics, and mitochondrial biogenesis (Quinn et al., 2020)