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Furthermore, this PROTAC showed in vivo activity, being well-tolerated

Melatonin exerts distinctly protective effects on ILC2-mediated AHR Building on our observations that melatonin offered protective effects, restraining the emergence of airway hyperreactivity in our murine models of asthma, we next aimed to identify if this could be applied more specifically to ILC2 activity in vivo

Further experiments on SD rats involved leg injection of 2.5 mg/mL dexamethasone to construct an osteoporosis rat model, with shikonin administered via leg injection for intervention

Jul 2009;1790(7):682-693

Animal 15: 100255

doi: 10.1016/j.jneumeth.2009.03.017